What type of disorder is Cri du Chat?

Children with Cri du Chat syndrome can have mild to severe intellectual disability . This might include language difficulties ranging from mild speech delay to severe language disorder. Some children might never be able to talk.3 Ara 2021

In infancy this diagnosis may be suspected because of the high-pitched cry and attacks of stridor and choking. In late childhood, when the signs may be only of a neurological disorder , its recognition may be difficult without confirmation from chromosome studies. The neurological features of this disease are reviewed.

Cri du chat syndrome is a chromosomal disorder caused by a partial deletion (monosomy) of a varying length of the short arm (p) of chromosome 5. Chromosomes, which are present in the nucleus of human cells, carry the genetic information for each individual.

Cri-du-chat syndrome occurs in an estimated 1 in 20,000 to 50,000 newborns . This condition is found in people of all ethnic backgrounds.