If you want to separate your project into a Django backend, and a frontend SPA, which only consumes data via a REST API, you’d be very well advised to use a frontend framework. When you’re thinking about decoupling, you should be sure that it’s well motivated.
Read moreCan you use Django without a database?
However, while you can use django with no database , the object-relational mapper is pretty much its first and foremost advertised feature. Django was designed to produce database-backed web sites, so if you’re not going to use a database you might end up dealing with a bunch of unnecessary hassle.
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