SVT amiodarone

Dronedarone has been viewed as a potential therapeutic alternative for amiodarone because of a lower risk for pulmonary, thyroid, and dermatologic adverse effects. Compared with amiodarone, dronedarone has poor bioavailability and a shorter terminal disposition half-life, which dictates a twice-daily dosing regimen.

Dronedarone (Multaq), an analogue of amiodarone (Cordarone), was designed to cause fewer adverse ef- fects than the parent compound. Studies have indeed shown dronedarone to be safer than amiodarone, but less effective .

Amiodarone is considered the most potent antiarrhythmic agent. The adverse event profile with amiodarone can be intolerable, with gastrointestinal effects the most common side effect.19 Şub 2020

3. Mechanism of action. Amiodarone is a Class III antiarrhythmic agent [7, 8] that prolongs the duration of action potential and hence increases the refractory period of atrial, nodal and ventricular tissues, thereby has a very broad spectrum of activity.