Should I learn tkinter or PyQt5?

PyQt can be hard to learn,especially for beginners, whereas if you get a brief on GUI development, by practicing primitive GUIs using Tkinter, you can then start with PyQt . The more you learn, the better you become. As Tony Flurry said, tkinter is quite primitive but is the most user friendly.

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Can you use tkinter and PyQt together?

In order to have both the Tkinter and Qt versions working simultaneously, I had to fork the process – and start each toolkit in a separate running instance ; Your case is not identical, as the Qt GUI will be already running, but maybe having this to start up with you can come along with a work-around.

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