Even though it is possible to play games with Genymotion, it has not been designed for this use . Also, some modern games, such as PokemonGo, include anti-root detection routines which make them incompatible with Genymotion.
Read moreCan I use Genymotion without Android Studio?
By default, Genymotion Desktop uses its own Android tools . In Settings > ADB, you can configure Genymotion Desktop to use specific Android tools (from Android Studio, for example). Use Genymotion Android tools (default) is the option enabled by default.
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