Contraindications: Patients with severe sinus-node dysfunction, causing marked sinus bradycardia; second- and third-degree atrioventricular block; and when episodes of bradycardia have caused syncope (except when used in conjunction with a pacemaker). Patients with a known hypersensitivity to the drug.
Read moreIs amiodarone contraindicated in atrial fibrillation?
Amiodarone is used in the treatment of atrial fibrillation, although the FDA has not approved this indication .
Read moreWhat is the best antiarrhythmic drugs in atrial fibrillation?
Amiodarone is considered the most potent antiarrhythmic agent. The adverse event profile with amiodarone can be intolerable, with gastrointestinal effects the most common side effect.
Read moreWhat is the safest antiarrhythmic drug?
Dronedarone was the best tolerated of the antiarrhythmic drugs, with the lowest rates of severe adverse events and a significant reduction in the risk of stroke. It is our practice to use propafenone, flecainide, sotalol, and dronedarone as first-line therapies in patients without structural heart disease (Table 4).17 Oca 2012
Read moreIs there a better drug than amiodarone?
Dronedarone has been viewed as a potential therapeutic alternative for amiodarone because of a lower risk for pulmonary, thyroid, and dermatologic adverse effects. Compared with amiodarone, dronedarone has poor bioavailability and a shorter terminal disposition half-life, which dictates a twice-daily dosing regimen.
Read moreIs Multaq better than amiodarone?
Dronedarone (Multaq), an analogue of amiodarone (Cordarone), was designed to cause fewer adverse ef- fects than the parent compound. Studies have indeed shown dronedarone to be safer than amiodarone, but less effective .
Read moreWhat is the most effective antiarrhythmic drug?
Amiodarone is considered the most potent antiarrhythmic agent. The adverse event profile with amiodarone can be intolerable, with gastrointestinal effects the most common side effect.19 Şub 2020
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